Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. Department of Oncology Medicine, Gustave Roussy Cancer Campus, Villejuif, France. Department of Medical Oncology, Georgetown Lombardi University Hospital, Lombardi Comprehensive Cancer Center, Washington, DC, USA. Urologic Oncology, Baylor Sammons Cancer Center-Texas Oncology, Dallas, TX, USA. Department of Internal Medicine, University of Pavia Chief, Division of Translational Oncology, IRCCS Istituti Clinici Scientifici Maugeri, Pavia, Italy. Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. AVEO Oncology, Boston, MA, USA. Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA. Hematology and Oncology, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA. Electronic address: brian.rini@vumc.org.